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Valproate should not be administered to a girl of childbearing probable Until the drug is crucial to your management of her health-related affliction.

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Considering the fact that individuals have been also treated with other antiepilepsy medication, it really is not possible, typically, to find out whether the next adverse reactions might be ascribed to Depakote by itself, or the combination of Depakote and other antiepilepsy medications.

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While there isn't any efficacy information that specifically address extended-expression antimanic remedy with Depakote, the protection of Depakote in prolonged-phrase use is supported by facts from record opinions involving approximately 360 patients treated with Depakote for greater than three months.

Based on two placebo-controlled medical trials as well as their lasting extension, valproate was generally effectively tolerated with most adverse reactions rated as moderate to moderate in severity. In the 202 clients subjected to valproate in the placebo-controlled trials, 17% discontinued for intolerance.

This document does not include all feasible Unwanted effects and Other folks may possibly arise. Examine using your medical doctor for additional information about side effects.

Youngsters under the age of two several years are at a noticeably enhanced danger of acquiring deadly hepatotoxicity, Specifically Those people on multiple anticonvulsants, Individuals with congenital metabolic Conditions, Those people with intense seizure Problems accompanied by mental retardation, and those with natural and organic brain illness.

Pertaining to breastfeeding, caution is advised since valproate does go into breast milk in little quantities.

Serum valproic acid concentrations should be monitored usually after initiating carbapenem therapy. Different antibacterial or anticonvulsant therapy should be regarded if serum valproic acid concentrations fall considerably or seizure Regulate deteriorates [see WARNINGS AND Safety measures].

Depakote Sprinkle Capsules may be swallowed whole, or the capsule could be opened and the contents could possibly be blended into a small volume of gentle foodstuff, such as applesauce or pudding.

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Patients receiving valproate and ethosuximide, Particularly in conjunction with other anticonvulsants, should be monitored for alterations in serum concentrations of each prescription drugs.

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